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2.3. Technical Partner/ Resource Identification: Once the topics are selected a

potential Technical Partner/ Resource Centre is identified by the Secretariat,

depending upon their area of expertise, capacity and previous experience, to take up

that topic to conduct HTA study. TAC can also suggest a suitable technical partner/
resource centre for a particular topic allocation.

2.4. Proposal Development: Technical Partner/ Resource Centre is asked to develop

a formal HTA proposal that contains the Policy Question, Research Question, Aims

and Objectives, PICO, Methodological Details, Expected Outcomes, Budget Impact,
Budget and Timeline etc. During the proposal development the team needs to do the

preliminary work on the topic in order to look for the availability of enough data. The

proposal is presented in the Technical Appraisal Committee Meeting and reviewed

thoroughly by the members and subject experts. TAC may approve the proposal or

provide comments/ suggestions and ask the for clarification/ revision in the proposal
wherever required. Once approved by the TAC, funds are sanctioned to the TP/RRC

to conduct the HTA study.

2.5. Research and Analysis: After the TAC approval the Technical Partner/ Resource

Centre start doing the research and analysis that included evidence synthesis for

clinical effectiveness and cost effectiveness mainly from published literatures/
secondary data sources like Medline, Cochrane, OVID and other national/

international/ Government data sources. In case of new drug/ devices when there is

a scarcity of data TP/ RRC may go for primary data collection with the approval of

TAC or drop the study during proposal development stage.

The evidence synthesis includes Systematic/ Rapid Review, meta-analysis,
data extraction etc. and the analysis include running the simulation models,

calculating the ICERS and Budget Impact Analysis etc. The analysis should also

consider the equity issues for the accessibility and affordability.

2.6. Appraisal of evidences: Once the study is complete the Outcome Report along

with the recommendations is presented to the TAC for appraisal. TAC (including
subject experts) review the proposal thoroughly and it may approve the report or

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