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4) Research and Analysis

Objectives:
 To collect and collate all the data relevant to informing the analyses. This will

include literature review, as well as direct evidence submission from appropriate

experts (and perhaps unpublished data), Government data sources etc..

 To undertake a detailed economic evaluation of the allocated research topic(s)

according to the methods outlined in the methods manual/ reference case to

address the key question(s) of assessment.

 Address the equity issues, if any.
 To write a formal HTA report based on the results of the analysis.

Activities:

 Undertaking systematic review/ rapid review

 According to the agreed Scope and PICO to inform meta-analysis of clinical

benefit and other key outcomes, where appropriate.
 If existing Systematic Review, Health Technology Assessments study and

related models were identified during scoping – these should be reviewed

against an internationally-recognized quality checklist (e.g. Drummond’s,

INAHTA, 2007 or R-AMSTAR Checklists)

 For interventions that are not yet formally adopted within the health system,
written submissions to request access to data should be made to any party that

is known or suspected to have unpublished data relating to the intervention,

including manufacturers and clinical or public health research institutions.

 Approval from ethical and scientific committee should be obtained, if required.

 Economic Evaluation (According to Methods annual):
 Undertaking Cost Effective/ Cost Utility/ Cost Benefit Analysis as per the

requirement

 Analytic Modelling – Decision Tree or, Markov Modelling as per the

requirement.

 If there is any equity issue regarding the feasibility of implementation,
accessibility and usage of the healthcare intervention TP/ RRC needs to address

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