Page 53 - Htain Manual

To summarize the illustration whenever we start framing we have a policy question

that has to be addressed on which the HTA question is centred. For this, there are four major

topics that need to be addressed; first of which is the technology in question and data relevant

to the same in terms of their efficacy, safety, clinical effectiveness, etc. and the same for all
alternatives being used as comparators. Second, come the patient related issues like the

impact of the health technology, access, affordability and the acceptability in terms of any

socio-cultural, ethical or equity issues. Third is the economic evidence in terms of the costs
incurred and the overall cost-effectiveness of the health interventions in question. The costs

and their analysis will be covered in later chapters in detail. Last is the organization being

affected by the whole intervention and its implementation; does it need to be reengineered

or does it require any kind of modification. All this data is collected and pooled together to be

sifted through and analysed, individually as well as collectively, the evidence is then
synthesized to extract a consolidated result in the form of an HTA report.

The whole process can be broken down in to the following steps::

 Defining the policy question

 Framing the methodological protocol

 Systematic review of all available evidence

 Mathematical modelling and evaluation

 Analysis of further impacts (equity, budget, etc.)

 Compiling the final report

Now once the policy question has been identified and the HTA question framed, we

need to look at all the parameters that need to be incorporated in the HTA proposal. The
proposal should have all the factors listed below explained in brief and to the point. (explicit).

The points explain the questions that a proposal covers and the expected information needed

from the investigator.

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